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. 2024 Feb 27;14(10):7006–7021. doi: 10.1039/d4ra00123k

Comparison of some other procedures with the present method for the synthesis of 1a.

Entry Catalysts Temperature (°C) Time (h) Yield (%) Ref.
1 Trifluoroethanol (TFE) (2 mL) Reflux 6 80 60
2 1-Butyl-3-methylimidazolium hydroxide (2 mL) 80 4 82 61
3 Cu/C nanocatalyst (2 mol%), CH3CN (2 mL) 80 8 84 62
4 Graphene oxide (10 mol%)/water (3 mL) 80 5 86 63
5 ETG-acetamide (50 mg) 80 3 71 This work