REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-mouse PD-L1 antibody	Bio X Cell	Cat#BE0361; RRID:AB_2927503
Anti-mouse SLC7A11 antibody	Proteintech	Cat#26864-1-AP; RRID:AB_2880661
Anti-mouse MerTK antibody	SAB Signalway Antibody	Cat#32851
Anti-mouse p-MerTK antibody	SAB Signalway Antibody	Cat#13320
Anti-mouse ki67 antibody	Abcam	Cat# ab92742; RRID:AB_10562976
Anti-mouse CD3 antibody	Abcam	Cat#ab16669; RRID:AB_443425
Anti-mouse CD8 antibody	Abcam	Cat#ab237709; RRID:AB_2892677
Anti-mouse CD11b antibody	Abcam	Cat#ab52478; RRID:AB_868788
Anti-mouse Gr1 antibody	Abcam	Cat#ab25377; RRID:AB_470492
Anti-mouse ERK 1/2 antibody	Cell Signaling Technology	Cat#9102; RRID:AB_330744
Anti-mouse p-ERK1/2 (T202/Y204) antibody	Cell Signaling Technology	Cat#4370; RRID:AB_2315112
Anti-mouse SP1 antibody	Proteintech	Cat#21962-1-AP; RRID:AB_10898171
Anti-mouse p-SP1 (T453) antibody	Abcam	Cat#ab59257; RRID:AB_946335
Anti-human CD15 antibody	Abcam	Cat#ab135377
Anti-human CD14 antibody	Abcam	Cat#ab133335; RRID:AB_2889158
Anti-human CD11b antibody	Abcam	Cat#ab133357; RRID:AB_2650514
Anti-mouse β-actin antibody	Proteintech	Cat#60008-1-Ig; RRID:AB_2289225
Anti-mouse IgG antibody	Bio X Cell	Cat#BE0089; RRID:AB_1107769
Anti-human HRP secondary antibody	Yuanxibio	Cat#A10011-60
BUV395 anti-mouse CD45 antibody	BD Biosciences	Cat#564279; RRID:AB_2651134
PE/cy7 anti-mouse CD3 antibody	BioLegend	Cat# 100219; RRID:AB_1732068
BV/785 anti-mouse CD4 antibody	BioLegend	Cat#100552; RRID:AB_2563053
BV/510 anti-mouse CD8 antibody	BioLegend	Cat#100752; RRID:AB_2563057
Bv421 anti-mouse IFN-γ antibody	BioLegend	Cat#505829; RRID:AB_10897937
PE anti-mouse CD11b antibody	BioLegend	Cat#101208; RRID:AB_312791
FITC anti-mouse Ly6G antibody	BioLegend	Cat#127606; RRID:AB_1236494
Bv421 anti-mouse Ly6C antibody	BioLegend	Cat# 128031; RRID: AB_2562177
Percp/cy5.5 anti-mouse Gr1 antibody	BioLegend	Cat#108428; RRID:AB_893558
APC anti-mouse F480 antibody	BioLegend	Cat#123115; RRID:AB_893493
Bacterial and virus strains
Escherichia coli	Tsingke	Cat# Tsingke-001
Biological samples
Human PAAD tissue microarrays	Huashan Hospital	N/A
Chemicals, peptides, and recombinant proteins
Sitravatinib	MCE	Cat#HY-16961
SYBR	TaKaRa	Cat#RR067A
Red blood cell lysis buffer	Tiangen	Cat#RT122-01
CFSE	Invitrogen	Cat# 65-0850-84
BODIPY 581/591 C11	Invitrogen	Cat# D3861
Pkh67 Green Fluorescent Cell Linker Kit	Sigma-Aldrich	Cat# PKH67GL
Propidium iodide	Invitrogen	Cat#P1304MP
SYTOX Green	Invitrogen	Cat#S7020
Critical commercial assays
IFN-γ ELISA Kit	R&D Systems	Cat# MIF00
CSF3 ELISA Kit	R&D Systems	Cat# MCS00
Tumor Dissociation Kit	Miltenyi Biotec	Cat#130-096-730
Cell Counting Kit-8	Dojindo	Cat#CK04-11
MDSCs Isolation Kit	Miltenyi Biotec	Cat#130-094-538
Zombie NIRTM Fixable Viability Kit	BioLegend	Cat#423105
Critical commercial assays
Lipid Peroxidation MDA Assay Kit	Beyotime	Cat#S0131S
Deposited data
Raw and analyzed expression profiling by array	https://www.ncbi.nlm.nih.gov/geo/	GEO: GSE76427
Raw and analyzed expression profiling by array	https://www.ncbi.nlm.nih.gov/geo/	GEO: GSE36376
Proteomics data	This paper; iProX Data	iProX: IPX0007790000
Experimental models: Cell lines
Human: 293T	Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Shanghai China	Cat# SCSP-502
Human: HepG2	Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Shanghai China	Cat# SCSP-510
Human: Hep3B	Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Shanghai China)	Cat# SCSP-5045
Human: Huh7	Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Shanghai China)	Cat# SCSP-526
Human: MHCC97-H	Liver Cancer Institute, University of Fudan University, China	N/A
Human: HCC-LM3	Liver Cancer Institute, University of Fudan University, China	N/A
Mouse: Hepa1-6	Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Shanghai China	Cat# SCSP-512
Experimental models: Organisms/strains
Mouse: C57BL/6	Beijing Vital River Laboratory	Cat#219
Mouse: C3H	Beijing Vital River Laboratory	Cat#212
Oligonucleotides
shRNA target sequences for SLC7A11/MerTK, see Table S1	This paper	N/A
SLC7A11/MerTK cDNA clone, see Table S1	This paper	N/A
PCR primers for β-actin/SLC7A11/MerTK/Csf1/Csf2/Csf3/Cxcl1/Cxcl2, see Table S1	This paper	N/A
Recombinant DNA
pCDH-CMV-MCS-EF1-puro	Ke Lei Biological Technology	Cat# kl-zl-0287-01
psPAX	Ke Lei Biological Technology	Cat#12260-20ul
pMD2.G	Ke Lei Biological Technology	Cat#12259-20ul
pLKO.1-Puro	Ke Lei Biological Technology	Cat#kl-zl-0961-01
pCMV-Gag-pol	Ke Lei Biological Technology	Cat# kl-zl-0178-01
VSVG	Ke Lei Biological Technology	Cat# kl-zl-0955-01
Software and algorithms
Prism 9.0.0	GraphPad Software	https://graphpad.com/scientific software/prism/
RStudio (v1.4.1106)	RStudio	https://www.rstudio.com/
TIMER2.0	Dana Farber Cancer Institute	http://timer.cistrome.org/
FlowJo v10.7.2	BD Biosciences	https://www.flowjo.com/solutions/flowjo/downloads
Fiji	ImageJ	https://imagej.net/software/fiji/
SlideViewer	3DHISTECH	https://www.3dhistech.com/