Table 1.
Patient and procedure characteristics
| Patients with non-MRSA SSI | Patients with MRSA SSI | p-value | |
|---|---|---|---|
| N = 418 | N = 23 | ||
| Demographics | |||
| Age, median [IQR], and years | 55 [40, 66] | 53 [43, 69] | 0.558 |
| Male | 120 (28.7) | 10 (43.5) | 0.130 |
| Race | |||
| White | 184 (44.0) | 6 (26.1) | 0.086 |
| Black | 195 (46.7) | 12 (52.2) | |
| Other race or unknown | 14 (3.3) | 0 (0.0) | |
| Ethnicity | |||
| Hispanic | 26 (6.2) | 4 (17.4) | 0.048 |
| Not Hispanic or unknown | 392 (92.8) | 19 (73.9) | |
| Beta-lactam allergy | 89 (21.3) | 1 (4.3) | 0.044 |
| History of MRSA colonization or infection | 9 (2.2) | 4 (17.4) | 0.001 |
| Comorbidities | |||
| Diabetes | 104 (24.9) | 8 (34.8) | 0.268 |
| Active or previous smoker | 192 (45.9) | 11 (47.8) | 0.850 |
| Hypertension | 221 (52.9) | 9 (39.1) | 0.205 |
| Asthma or COPD | 87 (20.8) | 5 (21.7) | 0.205 |
| BMI, median [IQR] | 31 [26, 37] | 32 [27, 41] | 0.180 |
| BMI > 30 | 227 (54.3) | 14 (60.9) | 0.556 |
| Immunocompromised | 132 (31.6) | 4 (17.4) | 0.166 |
| Malignancy | 118 (28.2) | 2 (8.7) | 0.037 |
| Receiving prednisone 10mg > = 30 days | 11 (2.6) | 1 (4.3) | 0.384 |
| HIV | 2 (0.5) | 1 (4.3) | 0.051 |
| Primary immunodeficiency | 1 (0.2) | 0 (0.0) | 0.359 |
| History of solid organ transplantation | 1 (0.2) | 0 (0.0) | 0.359 |
| Procedure characteristics | |||
| Index procedure | |||
| Hip or knee replacement | 36 (8.6) | 7 (30.4) | 0.003 |
| Colorectal surgery | 125 (29.9) | 3 (13.0) | 0.086 |
| Abdominal or vaginal hysterectomy | 81 (19.4) | 3 (13.0) | 0.543 |
| C-section | 58 (13.9) | 3 (13.0) | 0.932 |
| CABG or open chest procedure | 54 (12.9) | 2 (8.7) | 0.705 |
| Spinal fusion or laminectomy | 24 (5.7) | 2 (8.7) | 0.403 |
| Gastric surgery | 13 (3.1) | 2 (8.7) | 0.126 |
| Vascular surgery | 22 (5.3) | 1 (4.3) | 0.856 |
| Esophageal surgery | 5 (1.2) | 0 (0.0) | 0.767 |
| Emergent procedure | 17 (4.1) | 0 (0.0) | 0.580 |
| Wound class | |||
| I | 141 (33.7) | 12 (52.2) | 0.074 |
| II | 277 (66.3) | 11 (47.8) | |
| Procedure length, median [IQR], and hours | 3.9 [2.3, 5.5] | 2.6 [2.1, 4.7] | 0.289 |
| ASA status | |||
| 1 | 5 (1.2) | 0 (0.0) | 0.880 |
| 2 | 116 (27.8) | 6 (26.1) | |
| 3 | 235 (56.2) | 15 (65.2) | |
| 4 | 62 (14.8) | 2 (8.7) | |
| Received preoperative vancomycin | 102 (24.4) | 9 (39.1) | 0.181 |
| Hours before incision vancomycin infusion started, median [IQR] | 1.2 [0.5, 1.7] | 1.6 [1.2, 1.8] | 0.670 |
| Received other preoperative antibiotics | 402 (96.2) | 21 (91.3) | 0.190 |
| Received systemic antibiotics in the 90 days prior to surgery | 144 (34.4) | 8 (34.8) | 0.926 |
| Received MRSA decolonization prior to surgery | 36 (8.6) | 4 (17.4) | 0.139 |
| Received antibiotic bowel preparation/decontamination prior to surgery | 68 (16.3) | 2 (8.7) | 0.417 |
| Healthcare-associated characteristics | 126 (30.1) | 6 (26.1) | 0.857 |
| Hospitalized for >72 hrs within 90 days prior to procedure | 77 (18.4) | 4 (17.4) | 0.975 |
| Hospitalized for >72 hrs immediately prior to inpatient procedure | 69 (16.5) | 2 (8.7) | 0.401 |
| Received home wound care 30 days prior to procedure | 21 (5.0) | 2 (8.7) | 0.317 |
| SNF, LTAC, or nursing home resident immediately prior to procedure | 14 (3.3) | 0 (0.0) | 0.698 |
| CKD on chronic hemodialysis | 10 (2.4) | 0 (0.0) | 0.894 |
Note: Data are counted (%) unless otherwise specified. ASA, American Society of Anesthesiologists; SNF, skilled nursing facility; LTAC, long-term acute care.