TABLE 3.

Overlapping significantly enriched KEGG pathways based on KEGG enrichment of DEGs, GSEA, and WGCNA.

Trait	KEGG ID	Description	KEGG_DEGs q value	KEGG_GSEA q value	KEGG_WGCNA q value	Overlapping DEGs
IFC	ssc04931	Insulin resistance	<0.001	0.07	<0.001	INSR, PPARGC1A, PTPN1, TRIB3, IRS2, PRKAG2, SOCS3, GFPT2
	ssc04010	MAPK signaling pathway	0.002	0.052	<0.001	MAP2K3, FLNC, VEGFA, GADD45A, INSR, HSPB1, MAP3K8, GADD45G, MYC, IL1RAP
	ssc04920	Adipocytokine signaling pathway	0.002	0.071	<0.001	PPARGC1A, IRS2, PRKAG2, SOCS3
	ssc04066	HIF-1 signaling pathway	0.006	0.021	<0.001	VEGFA, INSR, IL6R, SERPINE1, HK3, TIMP1
	ssc04068	FoxO signaling pathway	0.02	0.029	<0.001	GADD45A, INSR, GABARAPL1, IRS2, PRKAG2, GADD45G
CIE a*	ssc04068	FoxO signaling pathway	0.002	<0.001	<0.001	GADD45A, GABARAPL1, IRS2, PRKAG2, GADD45B, FOXO1, IL6, PLK3, FBXO32
	ssc04920	Adipocytokine signaling pathway	0.005	0.097	<0.001	PPARGC1A, IRS2, PRKAG2, CPT1A, SOCS3
	ssc04010	MAPK signaling pathway	0.043	0.013	<0.001	GADD45A, FLNC, GADD45B, VEGFA, FGF6, DUSP1, IL1RAP, DUSP4, MYC, DUSP5, DUSP2
	ssc04066	HIF-1 signaling pathway	0.074	0.021	<0.001	SERPINE1, VEGFA, TIMP1, IL6, HK2