Table 3.
Predictive accuracy of each model
| Training cohort | Validation cohort | |||||
|---|---|---|---|---|---|---|
| J-ADNI | NP | NA-ADNI | ||||
| Model | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI |
| PRS and APOE alleles | ||||||
| APOE ε4 | 0.693 | 0.638–0.747 | 0.691 | 0.654–0.730 | 0.701 | 0.665–0.735 |
| APOE ε4 + ε2 | 0.696 | 0.640–0.751 | 0.698 | 0.659–0.737 | 0.712 | 0.675–0.750 |
| PRS.noAPOE | 0.640 | 0.576–0.704 | 0.550 | 0.500–0.599 | 0.602 | 0.559–0.649 |
| PRS.adjLD | 0.639 | 0.574–0.704 | 0.541 | 0.493–0.589 | 0.594 | 0.552–0.640 |
| PRS.incAPOE | 0.706 | 0.643–0.764 | 0.628 | 0.590–0.625 | 0.679 | 0.639–0.720 |
| PRS.noAPOE + APOE ε4 + ε2 | 0.755 | 0.695–0.807 | 0.731 | 0.686–0.773 | 0.730 | 0.692–0.767 |
| PRS.adjLD + APOE ε4 + ε2 | 0.748 | 0.687–0.800 | 0.728 | 0.680–0.771 | 0.731 | 0.693–0.769 |
| PRS and all covariates | ||||||
| Age + Sex + (Education) + APOE ε4 | 0.837 | 0.788–0.883 | 0.725 | 0.681–0.770 | 0.710 | 0.670–0.750 |
| Age + Sex + (Education) + APOE ε4 + ε2 | 0.838 | 0.789–0.883 | 0.723 | 0.679–0.768 | 0.706 | 0.665–0.746 |
| Age + Sex + (Education) + APOE ε4 + ε2 + PRS.noAPOE | 0.855 | 0.808–0.898 | 0.737 | 0.693–0.780 | 0.722 | 0.683–0.761 |
| Age + Sex + (Education) + APOE ε4 + ε2 + PRS.adjLD | 0.853 | 0.806–0.897 | 0.733 | 0.690–0.777 | 0.718 | 0.678–0.757 |
Abbreviations: Age, age at examination; Education, years of education. Years of education were not provided in the NP cohort