Table 5.
Polygenic risk of conversion of MCI to AD
| 5a PRS.noAPOE | |||||||||
| All MCI subjects | MCI subjects without APOE ε4 | MCI subjects with APOE ε4 | |||||||
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| PRS (High group) | 1.301 | 0.847–1.998 | 0.230 | 2.216 | 1.058–4.643 | 0.035 | 0.985 | 0.770–1.259 | 0.902 |
| Age | 1.070 | 0.846–1.353 | 0.574 | 1.069 | 0.725–1.578 | 0.736 | 0.961 | 0.687–1.344 | 0.816 |
| Sex (Male) | 0.858 | 0.532–1.383 | 0.529 | 0.589 | 0.257–1.353 | 0.212 | 0.983 | 0.539–1.793 | 0.956 |
| Education year | 0.791 | 0.605–1.035 | 0.087 | 0.745 | 0.452–1.229 | 0.249 | 0.856 | 0.610–1.202 | 0.37 |
| PC1 | 0.939 | 0.769–1.146 | 0.534 | 0.769 | 0.541–1.093 | 0.143 | 1.034 | 0.795–1.343 | 0.806 |
| PC2 | 0.954 | 0.753–1.209 | 0.697 | 1.028 | 0.713–1.481 | 0.884 | 0.900 | 0.647–1.251 | 0.529 |
| APOE ε4 alleles | 1.604 | 1.153–2.230 | 0.005 | NA | NA | NA | 1.108 | 0.516–2.382 | 0.793 |
| APOE ε2 alleles | 1.447 | 0.440–4.755 | 0.543 | 1.665 | 0.492–5.635 | 0.412 | NA | NA | NA |
| Log-rank test (high vs low PRS) | 0.202 | 0.031 | 0.292 | ||||||
| 5b PRS.adjLD | |||||||||
| All MCI subjects | MCI subjects without APOE ε4 | MCI subjects with APOE ε4 | |||||||
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| PRS (High group) | 1.161 | 0.752–1.792 | 0.500 | 1.547 | 0.727–3.296 | 0.258 | 1.030 | 0.812–1.305 | 0.809 |
| Age | 1.137 | 0.902–1.433 | 0.278 | 1.251 | 0.819–1.912 | 0.301 | 1.011 | 0.742–1.379 | 0.943 |
| Sex (Male) | 0.736 | 0.445–1.219 | 0.234 | 0.571 | 0.234–1.394 | 0.219 | 0.808 | 0.425–1.538 | 0.516 |
| Education year | 0.927 | 0.714–1.205 | 0.573 | 0.873 | 0.531–1.435 | 0.592 | 0.962 | 0.689–1.344 | 0.821 |
| PC1 | 0.909 | 0.738–1.119 | 0.368 | 0.682 | 0.460–1.011 | 0.057 | 1.042 | 0.801–1.355 | 0.758 |
| PC2 | 0.927 | 0.733–1.173 | 0.529 | 1.006 | 0.697–1.452 | 0.975 | 0.910 | 0.663–1.249 | 0.558 |
| APOE ε4 alleles | 1.560 | 1.102–2.209 | 0.012 | NA | NA | NA | 1.201 | 0.543–2.658 | 0.651 |
| APOE ε2 alleles | 0.708 | 0.169–2.965 | 0.636 | 0.709 | 0.163–3.085 | 0.647 | NA | NA | NA |
| Log-rank test (high vs low PRS) | 0.236 | 0.174 | 0.650 | ||||||
Abbreviations: HR Hazard ratio, 95% CI 95% confidence interval, APOE apolipoprotein E
Cox proportional hazard model: Conversion/follow-up = PRS (Low = 0, High = 1) + Age + Sex (Female = 0, Male = 1) + Education year + PC1 + PC2 + APOE ε4 alleles + APOE ε2 alleles
HR, 95% CI, and p-value were calculated by a Cox proportional hazard model controlling age at examination, sex, education years, the first two PCs, and the doses of APOE ε4 and ε2 alleles. Statistically significant was highlighted in bold