Table 3.

Univariate and multivariate analysis of cancer-specific early mortality in the training cohort

Variables	Univariate analysis				Multivariate analysis
	OR	95%Cl	P		OR	95%Cl	P
Age (years)
≤ 57	Ref				Ref
58 ~ 75	1.824	1.174–2.861	0.008		1.092	0.668–1.792	0.727
≥ 76	6.302	3.87–10.305	<0.001		2.956	1.664–5.243	<0.001
Race
White	Ref
Black	1.219	0.653–2.119	0.506
Other	0.827	0.424–1.475	0.546
Gender
Female	Ref
Male	1.018	0.702–1.488	0.927
Histological type
Adenocarcinoma	Ref
Not adenocarcinoma	1.367	0.848–2.128	0.181
Grade
Well differentiated: I	Ref
Moderately differentiated: II	1.045	0.453–3.034	0.926
Poorly differentiated: III	2.058	0.855–6.126	0.142
Undifferentiated;anaplastic:IV	1.68	0.447–6.317	0.43
T Stage
T1	Ref				Ref
T2	0.461	0.131–1.269	0.171		0.458	0.113–1.487	0.225
T3	0.552	0.331–0.957	0.027		0.857	0.451–1.674	0.643
T4	0.736	0.418–1.329	0.296		0.885	0.437–1.822	0.737
N Stage
N0	Ref
N1	0.799	0.499–1.29	0.352
N2	1.274	0.805–2.042	0.306
CEA level
Positive	Ref				Ref
Negative	0.42	0.228–0.717	0.003		0.621	0.317–1.139	0.142
Tumor size
≤ 55	Ref				Ref
56 ~ 85	1.559	1.025–2.355	0.036		1.213	0.756–1.932	0.418
≥ 86	2.364	1.429–3.82	<0.001		2.578	1.432–4.57	0.001
Surgery
Yes	Ref				Ref
No	1.973	1.367–2.849	<0.001		1.503	0.929– 2.422	0.095
Chemotherapy
Yes	Ref				Ref
No	12.395	8.411–18.423	<0.001		8.812	5.668– 13.834	<0.001
Radiotherapy
Yes	Ref				Ref
No	3.283	2.091–5.387	<0.001		2.012	1.1913–3.516	0.011
Marital status
Married	Ref
Unmarried	1.271	0.882–1.833	0.197
Bone metastases
Yes	Ref				Ref
No	0.308	0.175–0.575	<0.001		0.285	0.145–0.584	<0.001
Brain metastases
Yes	Ref
No	430,000	3.963e-08–NA	0.975
Liver metastases
Yes	Ref				Ref
No	0.583	0.361–0.906	0.021		0.486	0.281–0.81	0.007
Lung metastases
Yes	Ref				Ref
No	0.406	0.281–0.589	<0.001		0.427	0.275–0.662	<0.001