Table 2.
Multivariable analysis of the relationship between ACE2 transcription and the number of SARS-CoV-2 secondary cases
| Multivariable Regression Models (Secondary Cases ~ ACE2 Transcription + RNA Viral Load + Case Description + ACE2 Transcription: Case Description) |
|||
|---|---|---|---|
|
Beta Coefficients
(95% CI) |
Poisson | Quasi-Poisson | Negative Binomial (NB) |
| ACE2 Transcription in HCW |
β -0.164 (-0.236- [-0.0919]) |
β -0.164 (-0.273-[-0.0528]) |
β -0.132 (-0.255- [-0.0181]) |
| RNA Viral Load |
β 2.73*10^-3 (5.34*10^-3–0.0976) |
β 2.73*10^-3 (-0.141-0.150) |
β -0.0197 (-0.164- [0.123]) |
| Case (Patient) |
β -0.808 (-1.20- [-0.421]) |
β -0.808 (-1.43- [-0.235]) |
β -0.782 (-1.42- [-0.162]) |
|
ACE2 Transcription in Patients |
β 0.208 (0.0958-0.320) |
β 0.208 (0.0382–0.382) |
β 0.187 (0.01011-0.370) |
| AIC | 394 | -- | 346 |
| Theta | 2.44 | 2.44 | 0.922 |
|
Score Test (P Value) |
P < 0.001 | -- | P = 0.976 |
All explanatory variables are features of the primary case, characteristics of the secondary cases are not included in the regression models (e.g., ACE2 transcription of the primary case). Model statistics shown are β-coefficients and 95% confidence intervals