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. 2024 Feb 27;12(2):e1199. doi: 10.1002/iid3.1199

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© 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Construction of a human intestinal epithelial cell line silencing KLF4 and detection of protein expressions. (A) The transcription level of KLF4 was significantly downregulated in KLF4‐silenced human intestinal epithelial cells. (B) Western blot identified that KLF4 protein was significantly downregulated in KLF4‐silenced human intestinal epithelial cells. (C–G) QPCR assay showed that TXNIP (C), NLRP3 (D), ASC (E), Caspase‐1 (F), and gasdermin D (G) levels were significantly decreased in lipopolysaccharide (LPS)/adenosine 5‐triphosphate (ATP)‐induced intestinal pyroptosis model. (H) Interleukin (IL)‐1β level was remarkably decreased in LPS/ATP‐induced intestinal pyroptosis model. (I) IL‐18 level was remarkably decreased in LPS/ATP‐induced intestinal pyroptosis model. *p < .5; ***p < .001.