Table 2.
Prevalence of a grade 3–4 chronic health conditions in survivors of allogeneic BMT in childhood alive at follow-up and sibling comparison cohort
| Variable | BMT survivors (N=540) | Siblings (N=690) | P-value | ||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Any grade 3–4 chronic health condition | 192 | 35.6 | 88 | 12.8 | <0.0001 |
| Specific chronic health conditions | |||||
| Subsequent malignant neoplasm | 80 | 14.8 | 2 | 0.3 | <0.0001 |
| Cataract | 47 | 8.7 | 8 | 1.2 | <0.0001 |
| Cardiovascular disease* | 27 | 5.0 | 7 | 1.0 | <0.0001 |
| Gastrointestinal disorder** | 19 | 3.5 | 5 | 0.7 | 0.0004 |
| Sensorineural disorder*** | 37 | 6.9 | 27 | 3.9 | 0.02 |
| Diabetes | 26 | 4.8 | 7 | 1.0 | <0.0001 |
| Joint replacement | 23 | 4.3 | 14 | 2.0 | 0.02 |
| Thyroid nodules | 22 | 4.1 | 11 | 1.6 | 0.008 |
| Blood clot | 12 | 2.2 | 15 | 2.2 | 1.0 |
| Lung fibrosis/lung transplant | 4 | 0.7 | 0 | 0.0 | 0.02 |
| Dialysis | 0 | 0.0 | 3 | 0.4 | 0.1 |
*
Includes heart attack, congestive heart failure, stroke, stiff or leaky valve, arrhythmia;
**
Includes liver disease, rectal disorders, or intestinal obstruction;
***
Includes hearing loss, balance/vertigo, legally blind