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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Mol Cell Neurosci. 2023 Mar 24;125:103849. doi: 10.1016/j.mcn.2023.103849

Figure 4.

Figure 4.

Cocaine-dependent transcriptional changes identified using pseudobulk differential expression analysis, a, Number of cocaine dependent DEGs in each identified cell type, b-d, Volcano plots for Drd1-MSN-1, Astrocyte, and Sst-Interneuron populations. e, Cocaine dependent changes for 4 different immediate early genes in the Drd1-MSN-1 and Drd1-MSN-2 populations (One-way ANOVA test with Tukey’s multiple comparison test:****p<0.0001, ns: not significant). f-h, Heatmap showing log2(Fold Change) of all cocaine DEGs in Drd1-MSN-1, Astrocyte, and Sst-interneuron populations, regardless of length of cocaine exposure. i, Interpretation key for rank-rank hypergeometric overlap (RRHO) heatmaps. Quadrants I and III represent discordant gene expression changes, while quadrants II and IV represent concordant gene expression changes. j-l, RRHO heatmaps for Drd1-MSN-1, Astrocyte, and Sst-Interneuron.