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. 2023 Oct 27;120(1):56–68. doi: 10.1093/cvr/cvad166

Figure 3.

Figure 3

Rbpms cKO hearts display cardiomyocyte contractile defects. (A) Representative sarcomere shortening images of single isolated CTL and cKO cardiomyocytes at 2 months of age. (B–D) Measurements of sarcomere fractional shortening at peak contraction, shortening velocity, and relaxation velocity of individual cardiomyocytes during the contraction cycle (n = 6 for CTL and n = 5 cKO mice at each stage, average 10–20 cardiomyocytes per mouse). (E) Quantification of the number and frequency of abnormal contraction in single isolated CTL and cKO cardiomyocytes at 2 months of age. (F) Measurements of twitch force of isolated cardiac papillary muscles from CTL and cKO mice at 2 months of age (n = 4 for CTL and n = 6 cKO mice). (G) Representative recordings of stimulated twitches of cardiac papillary muscle from CTL and cKO mice with a beating rate of 1 Hz. All data are presented as mean ± SEM. *P < 0.05; ***P < 0.001, by Student’s t-test two-tailed for B, C, D, F.