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. 2023 Oct 25;120(1):82–94. doi: 10.1093/cvr/cvad158

Figure 3.

Figure 3

Effects of TNF-α deficiency in the TCRM model. (A) Mortality of TCRM mice up to age of 16 weeks (Tnf+/+ n = 45, Tnf+/−  n = 39, Tnf−/−  n = 35). (B) Myocarditis severity in 6-week-old and 12-week-old mice and in non-survivors (mice meeting humane endpoints, age 4–10 weeks, n = 8–12 per group) and representative examples of age- and sex-matched healthy heart of wild-type (Tnf+/+) and TCRM × Tnf+/− and TCRM × Tnf−/− non-survivors. (C) Heart weight/tibia length (HW/TL) (n = 6). (D) Measurements of cross-sectional area of cardiomyocytes (n = 6). (E) Percentage of fibrotic area in cardiac sections (n = 6). (F) Representative microphotographs used in the analysis. P values calculated with log-rank test for A, Kruskal–Wallis test for B, or one-way ANOVA followed by multiple comparison using Fisher’s LSD test for C–E. ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001.