Table 2. Laboratory parameters in severe fever with thrombocytopenia virus-positive cats in the acute phase (day 0 to 7 after onset).
| Laboratory tests | Reference range | Total | Survival | Fatal | P value†† | |||
|---|---|---|---|---|---|---|---|---|
| n | Median (Min, Max) | n | Median (Min, Max) | n | Median (Min, Max) | |||
| Viral load | ||||||||
| In blood (copies/mL) | - | 74 | 3.2E+07 (9,993.3, 3.4E+10) | 29 | 1.4E+07 (1.0E+04, 8.1E+08) | 45 | 2.3E+08 (1.1E+05, 3.4E+10) | <0.001 |
| In swab§ (copies/mL) | - | 28 | 1.2E+04 (383, 1.1E+08) | 13 | 5.0E+03 (3.8E+02, 1.1E+08) | 15 | 2.5E+04 (7.9E+02, 5.3E+05) | 0.122 |
| Blood test | ||||||||
| RBC (×104/μL) | 500⁓1,000 | 66 | 778 (121, 1,146) | 26 | 782 (121, 1,146) | 40 | 765 (127, 1,122) | 0.135 |
| WBC (×/μL) | 5,500⁓19,500 | 77 | 0 (53, 2,000) | 31 | 3,040 (53, 17,300) | 46 | 1,999 (200, 13,340) | 0.121 |
| PLT (×104/μL) | 30⁓80 | 74 | 2 (0, 15) | 31 | 2 (0, 9) | 43 | 1 (0, 15) | 0.602 |
| Biochemical test | ||||||||
| T-Bil (mg/dL) | 0.0⁓0.1 | 61 | 4.5 (0.1, 14.0) | 25 | 3.0 (0.1, 11.3) | 36 | 4.7 (1.1, 14.0) | 0.011 |
| CPK (U/L) | 69⁓214 | 36 | 274.0 (0.6, 2,000**) | 17 | 134.0 (0.6, 2,000**) | 19 | 419.0 (1.7, 2,000**) | 0.037 |
| ALT (U/L) | 25⁓97 | 56 | 56 (21, 2,000**) | 24 | 56 (21, 2,000**) | 32 | 59 (25, 1,000†) | 0.247 |
| AST (U/L) | 7⁓38 | 35 | 78 (24, 1,000†) | 15 | 68 (24, 150) | 20 | 100 (36, 1,000) | 0.072 |
| BUN (mg/dL) | 19⁓34 | 21 | 25.3 (1.2, 231.0) | 9 | 25.3 (11.0, 231.0) | 12 | 25.3 (1.2, 141.0) | 0.374 |
| Cre (mg/dL) | 0.9⁓2.2 | 43 | 1.01 (0.32, 22.6) | 20 | 1.05 (0.78, 22.6) | 23 | 0.94 (0.32, 1.92) | 0.156 |
| TP (g/dL) | 6.0⁓7.9 | 32 | 8.4 (5.3, 11.0) | 10 | 9.4 (7.1, 10.4) | 22 | 8.2 (5.3, 11.0) | 0.207 |
| Glu (mg/dL) | 6.0⁓7.9 | 25 | 211 (18, 420) | 6 | 205 (101, 345) | 19 | 228 (18, 420) | 0.356 |
| SAA (μg/mL) | ≤0.82 | 63 | 70.6 (10.4, 143.6) | 23 | 61.4 (10.4, 112.5) | 40 | 82.4 (37.8, 143.6) | 0.002 |
| IgM (OD) | - | 82 | 0.38 (0, 2.38) | 32 | 0.58 (0.02, 2.38) | 50 | 0.34 (0.00, 1.67) | 0.028 |
| IgG (OD) | - | 82 | 0.12 (0, 1.98) | 32 | 0.23 (0.00, 1.98) | 50 | 0.09 (0, 1.61 | 0.019 |
| Cytokines | ||||||||
| TNF-α (pg/mL) | -* | 33 | 15.30 (1.03, 492) | 13 | 14.45 (1.03, 27.7) | 20 | 21.95 (2.31, 492) | 0.034 |
| IL-1β (pg/mL) | -* | 57 | 7.39 (0, 15,568) | 22 | 0.17 (0, 15,568) | 35 | 16.65 (0, 3,682) | 0.083 |
| IL-6 (pg/mL) | -* | 41 | 125.56 (0, 35,727) | 15 | 0 (0, 35,727) | 26 | 312.39 (0, 23,253) | 0.005 |
Red blood cell (RBC), white blood cell (WBC), platelet (PLT), total bilirubin (T-Bil), creatinine phosphokinase (CPK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cre), total protein (TP), glucose (Glu), serum amyloid A (SAA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). *Cut off values were determined as <50 ng/mL for TNF-α, <16 pg/mL for IL-1β, and <31.3 pg/mL for IL-6, in this study. **Maximam value was determined as 2,000. †Maximam value was determined as 1,000. †† Wilcoxon signed-rank test was used to compare between survival and fatal group. §The swab samples comprised oral and rectal swabs.