Figure 4.

MECP2 null networks reverberate more than isogenic controls and exhibit greater bursting activity, indicating hyperactivity. (A) Proportion of reverberating, mixed reverberation, and nonreverberation wells relative to the total number of bursting wells across development for each individual. (B) Network reverberation index, representing the plate-matched difference in proportion of reverberating networks for each individual. (C) Mean number of network bursts per recording for NR-WT and R-NULL networks. All bar plots use mean ±95% CIs. Statistical significance was evaluated using Kruskal–Wallis tests and 2-way analysis of variance. ∗∗∗p < .001. RSB, reverberating super burst; RTT, Rett syndrome; WT, wild-type.