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. 2024 Jan 24;4(2):100290. doi: 10.1016/j.bpsgos.2024.100290

Figure 5.

Figure 5

RSBs alter network bursting metrics. (A) Wild-type and MECP2 null WIBR3 networks were stratified as either nonreverberating or reverberating. (B, C) Quantification of (B) network event duration and (C) network event frequency between nonreverberating control networks (NR-WT), nonreverberating mutant networks (NR-NULL), and reverberating mutant networks (R-NULL). Network event refers to the entire RSBs (initiation network burst and minibursts) in reverberating networks or discrete single-network bursts in nonreverberating networks. (D) Quantification of the number of minibursts per RSB of reverberating WIBR3 WT (R-WT) and WIBR3 null (R-NULL) networks. (E) Quantification of RSB duration of reverberating R-WT and R-NULL networks. (F) Linear regression of number of minibursts per RSB and RSB duration in R-NULL networks suggests the long network burst duration is associated with an increased number of minibursts that were unaccounted for. (G) Quantification of reverberating miniburst frequency of R-WT and R-NULL networks. (H) Distribution of initiation burst duration in reverberating (R-WT and R-NULL) networks and discrete single-network burst duration of nonreverberating (NR-WT and NR-NULL) networks. (I) RANSAC regression of miniburst frequency and initiation burst duration in week 6 R-NULL networks suggests that a longer initiation burst duration is associated with increased reverberating miniburst frequency. Lighter colored points indicate RANSAC outliers. Darker colored points indicate RANSAC inliers. Linear fit performed on RANSAC inliers. See RANSAC Regression under Supplemental Materials and Methods 4.10. (J) RANSAC regression of number of minibursts per RSB and initiation burst duration in week 6 R-NULL networks suggests longer initiation burst duration is associated with increased number of minibursts that follow. Lighter colored points indicate RANSAC outliers. Darker colored points indicate RANSAC inliers. Linear fit performed on RANSAC inliers. See RANSAC regression under Supplemental Materials and Methods 4.10. All bar plots use mean ± 95% CIs. Statistical significance was evaluated using 2-way analysis of variance, Kruskal–Wallis test, linear regression, and RANSAC regression. ∗p < .05, ∗∗p < .01, ∗∗∗p < .001. NE, network event; NR, nonreverberating; R, reverberating; RANSAC, random sample consensus; RSB, reverberating super bursts; WT, wild-type.