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. 2023 Nov 23;5(2):240–261. doi: 10.1038/s43018-023-00668-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a–d, Frequency of the indicated cell types in B16F10 tdLNs and tumors of mice treated with cytokine-armed DCPs or moDCs (mean ± SEM; PBS, n = 7 mice; DCP-IL-12/FLT3L, n = 7; moDC-IL-12/FLT3L, n = 7-8). Statistical analysis by one-way ANOVA with Tukey’s multiple comparison test (black p values) or two-tailed Mann-Whitney test (red p values). e, Schematic of the bicistronic LV construct used to co-express IL-12 and FLT3L. f, Growth of individual B16F10 tumors in mice (PBS, n = 8 mice; DCP-IL-12/FLT3L (1 × 10⁶), n = 7; moDC-IL-12/FLT3L (1 × 10⁶), n = 6; moDC-IL-12/FLT3L (2 × 10⁶), n = 7). g, MC38 tumor growth in mice. Data show tumor volume (mean ± SEM; n = 8 mice). Statistical analysis by two-way ANOVA with Tukey’s multiple comparison test (not significant). h-i, Frequency of the indicated cell types in MC38 tumors (mean ± SEM; PBS, n = 8 mice in (h) and n = 7 in (i); DCP-IL-12, n = 7; DCP-FLT3L, n = 8 in (h) and n = 7 in (i)). Statistical analysis by one-way ANOVA with Tukey’s multiple comparison test. Each data point represents one sample or tumor measurement from an independent mouse, except for (g) in which each point represents the mean volume of independent tumors.

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