Table 2.
Change in echo variables from baseline to weeks 26 and 52 (Echo subgroup, N = 45)
| Echo variables | n | Baseline Mean (SD) | Change from baseline to week 26 LS meana (95% CL) | n | Change from baseline to week 52 LS meana (95% CL) |
|---|---|---|---|---|---|
| RV fractional area change, % | 42 | 25.9 (11.9) | 7.5 (4.4, 10.7) | 38 | 7.1 (4.3, 9.9) |
| TAPSE, mm | 39 | 16.4 (3.5) | 2.5 (1.4, 3.6) | 35 | 3.2 (2.2, 4.2) |
| 2D global longitudinal RV strain, % | 36 | − 13.9 (5.7) | − 3.0 (− 4.7, − 1.4) | 33 | − 3.5 (− 4.9, − 2.1) |
| RV stroke volumeb, mL | 28 | 68.4 (22.6) | 11.6 (3.2, 20.0) | 25 | 15.5 (4.6, 26.5) |
| RV stroke volume index, mL/m2 | 28 | 39.1 (12.8) | 5.9 (1.7, 10.1) | 25 | 8.7 (2.2, 15.2) |
| RV cardiac index, L/min/m2 | 28 | 2.9 (1.0) | 0.23 (− 0.10, 0.57) | 25 | 0.46 (− 0.03, 0.94) |
| RV cardiac output, L/min | 28 | 5.1 (1.9) | 0.47 (− 0.12, 1.06) | 25 | 0.81 (0.02, 1.60) |
| LV stroke volumec, mL | 29 | 51.5 (18.2) | 9.6 (3.8, 15.5) | 25 | 11.9 (5.1, 18.6) |
| RV myocardial performance indexc | 29 | 0.69 (0.38) | − 0.20 (− 0.26, − 0.15) | 25 | − 0.30 (− 0.40, − 0.20) |
| Mitral E/A ratio | 35 | 0.95 (0.35) | 0.19 (0.06, 0.32) | 31 | 0.30 (0.16, 0.44) |
| RV end-diastolic diameter, mm | 43 | 45.3 (7.1) | − 2.8 (− 4.7, − 0.8) | 38 | − 3.2 (− 5.1, − 1.4) |
| LV end-diastolic volume, mL | 32 | 70.6 (27.6) | 15.1 (8.8, 21.4) | 31 | 16.5 (8.9, 24.2) |
| Tricuspid regurgitation PJV, m/s | 21 | 4.3 (0.74) | − 0.36 (− 0.70, − 0.03) | 19 | − 0.29 (− 0.63, 0.05) |
| Heart rate, bpm | 43 | 78.3 (14.6) | − 7.0 (− 10.2, − 3.8) | 38 | − 8.2 (− 12.0, − 4.4) |
aAnalyzed using ANCOVA with a factor for PAH background therapy and a covariate for baseline parameter value
bDetermined from pulmonic valve Doppler and pulmonary artery annulus dimension
cBy pulsed-wave Doppler
ANCOVA analysis of covariance, bpm beats per minute, CL confidence limit, echo echocardiography, LS least squares, LV left ventricular, PAH pulmonary arterial hypertension, PJV peak jet velocity, RV right ventricular, SD standard deviation, TAPSE tricuspid annular plane systolic excursion