Table 3.
Change in cMRI variables from baseline to weeks 26 and 52 (Echo subgroup, N = 45)
| cMRI variables | n | Baseline Mean (SD) | Change from baseline to week 26a LS mean (95% CL) | n | Baseline Mean (SD) | Change from baseline to week 52a LS mean (95% CL) |
|---|---|---|---|---|---|---|
| RV stroke volume by flowb, mL | 38 | 48.9 (18.5) | 14.0 (9.4, 18.6) | 35 | 48.1 (19.1) | 17.3 (12.7, 21.8) |
| RV stroke volume by volumec, mL | 40 | 55.9 (19.1) | 15.2 (10.6, 19.7) | 35 | 56.0 (19.5) | 15.8 (11.1, 20.5) |
| RVEDV, mL | 40 | 149.0 (48.2) | 0.9 (− 7.3, 9.0) | 35 | 147.1 (44.1) | 3.1 (− 5.9, 12.0) |
| RVESV, mL | 40 | 93.1 (43.9) | − 15.2 (− 21.8, − 8.6) | 35 | 91.1 (39.0) | − 13.7 (− 22.4, − 5.0) |
| RV ejection fraction by flowb, % | 37 | 35.9 (16.1) | 9.3 (6.2, 12.4) | 34 | 34.9 (15.7) | 12.0 (7.7, 16.3) |
| RV ejection fraction by volumec, % | 40 | 39.7 (13.3) | 9.8 (7.1, 12.4) | 35 | 39.8 (12.8) | 10.5 (6.7, 14.3) |
| RV mass, g | 40 | 102.8 (40.7) | − 6.5 (− 12.2, − 0.9) | 35 | 103.8 (42.5) | − 2.7 (− 9.5, 4.1) |
| LV stroke volume by flowd, mL | 38 | 46.9 (17.2) | 16.1 (12.1, 20.2) | 34 | 46.2 (17.8) | 16.7 (12.5, 20.9) |
| LV stroke volume by volumec, mL | 40 | 53.3 (19.6) | 19.9 (15.6, 24.3) | 35 | 53.3 (20.6) | 17.5 (13.7, 21.3) |
| LVEDV, mL | 40 | 87.8 (28.9) | 21.3 (15.2, 27.5) | 35 | 88.1 (30.2) | 19.0 (13.6, 24.4) |
| LVESV, mL | 40 | 34.5 (17.0) | 1.3 (− 2.4, 4.9) | 35 | 34.8 (17.0) | 1.4 (− 2.4, 5.3) |
| LV ejection fraction by flowd, % | 37 | 53.7 (11.9) | 4.0 (0.9, 7.1) | 34 | 53.1 (11.9) | 7.3 (3.5, 11.1) |
| LV ejection fraction by volumec, % | 40 | 61.5 (12.9) | 6.2 (4.0, 8.4) | 35 | 61.2 (12.8) | 6.1 (3.8, 8.4) |
| LV mass, g | 40 | 102.7 (24.3) | 4.1 (0.8, 7.4) | 35 | 103.2 (25.5) | 5.3 (1.4, 9.2) |
| RVEDV/LVEDVe | 40 | 0.53 (0.32) | − 0.22 (− 0.29, − 0.16) | 35 | 0.52 (0.31) | − 0.19 (− 0.26, − 0.12) |
| RVESV/LVESVe | 40 | 1.00 (0.48) | − 0.23 (− 0.34, − 0.13) | 35 | 0.99 (0.49) | − 0.23 (− 0.37, − 0.09) |
aAnalyzed using an ANCOVA with a factor for PAH background therapy and a covariate for baseline value
bDetermined from pulmonary artery flow
cDetermined from volume
dDetermined from aortic flow
eLog transformed
ANCOVA analysis of covariance, CL confidence limit, cMRI cardiac magnetic resonance imaging, echo echocardiography, LS least squares, LV left ventricular, LVEDV LV end-diastolic volume, LVESV LV end-systolic volume, PAH pulmonary arterial hypertension, RV right ventricular, RVEDV RV end-diastolic volume, RVESV RV end-systolic volume, SD standard deviation