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. 2024 Feb 27;15:1530. doi: 10.1038/s41467-024-45579-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a, b Measurement of serum concentration of bicarbonate ions during ischaemia and reperfusion. a Experimental design. The modified Neurological Severity Score (mNSS) was evaluated at 45 min of MCAO, and blood was collected before (−10 min) and after ( + 5 min) reperfusion. b Changes in serum bicarbonate levels in Gpr30^+/+ and Gpr30^+/Venus (left), Gpr30^−/−, Gpr30^−/Venus, and Gpr30^Venus/Venus (middle), and sham-operated (right) mice. A set of data collected at pre- and post-reperfusion from the same mouse are connected with a line (left box). The difference in serum bicarbonate concentration (Δbicarbonate (mM) post − pre) presented as dot plots with mean (right box). c–e Magnetic resonance angiography (MRA) analysis before and after reperfusion. c Experimental design. d Maximal intensity projection images before (top) and after (middle) reperfusion. Delineated MCA and branches after reperfusion are shown (bottom). e Vessel volume of the left MCA and its branches (reperfusion side) as a ratio to that of the right (control side). f–h Measurement of cerebral blood flow using laser Doppler flowmetry. f Experimental design. g Normalised blood flow as a ratio to the basal blood flow. h Area under the curve of the blood flow from 0 to 20 min during the reperfusion phase. Statistical analysis: b two-tailed paired t-test. e, h the main effect in two-way ANOVA. Data are presented as dot plots with median. P values are shown if significant. ns indicates no significant difference. Source data are provided as a Source Data file.