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Requirement of p300 for oxygen regulation. Cells were cotransfected with a vector expressing wild-type (WT) E1A or a vector expressing a mutant (mut) form of E1A which does not bind to p300. Hypoxic induction of the reporter, relative to α-globin control (α), was measured by RNase protection assay. Expression of E1A nearly abolished induction by hypoxia, whereas the mutated E1A did not affect hypoxic inducibility of the LDH-A promoter.
