Table 2.

SNPs used as instrumental variables from gut microbiome and intellectual disability GWASs (p < 5 × 10–8).

Classification		Nsnp	Methods	Beta	SE	OR (95%CI)	p-value	Test of heterogeneity		Horizontal pleiotropy
								Q	p-value	Egger intercept	SE	p-value
Family	Bifidobacteriaceae	1,228	MR Egger	−0.079	0.102	0.923 (0.775, 1.129)	0.436	0.000	1.000	0.002	0.010	0.815
			Weighted median	−0.240	0.016	0.786 (0.761, 0.812)	7.94E-38
			IVW	−0.056	0.012	0.946 (0.924, 0.967)	1.48E-06	0.000	1.000
			Weighted mode	−0.383	0.069	0.682 (0.596, 0.781)	3.43E-08
Genus	Enterorhabdus	25	MR Egger	0.406	0.082	1.444 (1.163, 1.689)	0.019	0.000	1.000	0.001	0.013	0.915
			Weighted median	0.408	0.088	1.504 (1.264, 1.789)	4.23E-06
			IVW	0.407	0.069	1.502 (1.313, 1.718)	3.25E-09	0.007	1.000
			Weighted mode	0.407	0.153	1.503 (1.114, 2.028)	0.013
	Ruminococcustorquesgroup	9	MR Egger	−1.89E-16	9.322	1.000 (0,86123175.177)	1.000	0.000	1.000	−0.052	0.559	0.928
			Weighted median	−0.869	0.215	0.419 (0.275, 0.638)	5.11E-05
			IVW	−0.871	0.169	0.419 (0.300, 0.583)	2.60E-07	0.009	1.000
			Weighted mode	−0.861	0.292	0.423 (0.239, 0.748)	0.018
	Tyzzerella3	10	MR Egger	−0.197	5.193	0.821 (0,21596.688)	0.970	0.006	1.000	−0.013	0.673	0.985
			Weighted median	−0.299	0.087	0.741 (0.624, 0.880)	0.0006
			IVW	−0.297	0.074	0.743 (0.642, 0.859)	6.17E-05	0.006	1.000
			Weighted mode	−0.301	0.129	0.740 (0.574, 0.954)	0.045
Class	Actinobacteria	36	MR Egger	1.250	0.517	3.491 (1.267, 9.621)	0.021	7.094	1.000	−0.099	0.053	0.073
			Weighted median	0.329	0.066	1.391 (1.221, 1.584)	6.72E-07
			IVW	0.299	0.052	1.350 (1.219, 1.494)	6.85E-09	10.507	1.000
			Weighted mode	0.327	0.110	1.387 (1.117, 1.722)	0.005
Phylum	Actinobacteria	14	MR Egger	−4.285	4.843	0.014 (0, 182.640)	0.393	6.014	0.915	0.327	0.409	0.440
			Weighted median	−0.509	0.127	0.601 (0.468, 0.770)	5.85E-05
			IVW	−0.414	0.101	0.661 (0.543, 0.805)	3.81E-05	6.653	0.919
			Weighted mode	−0.5097	0.175	0.601 (0.426, 0.847)	0.012