Table 3.
EEG and clinical responses to B6 exposure and follow-up EEG findings.
| Patient no. | Age at PN trial | EEG during PN trial | Clinical effect | ASM at PN trial | EEG follow up, 1st month, days after PN trial (+ d) | ||
|---|---|---|---|---|---|---|---|
| Type of recording | Pattern at start | Effect | |||||
| Improved EEG during PN trial | |||||||
| 1 | 2 h | aEEG | ED bil | Improvement | Response (< 1 h) | None | NA |
| 2 | 2 d | Standard | BS | Improvementa | Seizure free at start and during trial | PB | Normal (+8 d) |
| 10 | 3 d | LTM | BS | Improvementa | Promptb | DZP, PB, PHT | Normal (+5 d) |
| Unchanged EEG during PN trial | |||||||
| 3 | 2.5 mo | LTM | BS | None | None | CLZ, DZP, LDC, PB, VAL | Unchanged (+6 d) |
| 4 | 6 d | Standard | BS | None | Delayed (< 1 d) | LEV, PB | Improved (+6 d) |
| 6 | 2 d | aEEG | BS | None | Uncertain | LEV, MDZ, PB, PHT | Unchanged (+1 d)Improved (+3 d) |
| 7 | 5 d | LTM | BS | None | Seizure free at start and during trial | CBZ, LEV, MDZ, PB, PHT | Improved (+1 d)Normal (+2 d) |
| 8 | 20 d | Standard, LTM | ED L o | None | Seizure increase | CLZ, MDZ | Normal (+14 d) |
| 9 | 21 d | Standard | ED bil asynch | None | Promptb | CBZ, LDC, PB, PHT | Improved (+10 d) |
| Deterioration of EEG during PN trial | |||||||
| 11 | 2 d | Standard | ED MF | Increased ED | Promptb | BDZ, PB, PHT | Improved (+5 d) |
| 12 | 11 d | aEEG | ED | Conversion to BS | Promptb | DZP, PB, PHT | Normal (+20 d) |
| No PN trial/no EEG during PN trial | |||||||
| 5 | No PN trial, but peroral PLP from 18 d | NA | NA | NA | NA (PLP effect; PN from 24 d) | CLZ, MDZ, TPM, VPA | Unchanged (+4 d)Improved (+8 d) |
| 13 | 2 d | None | NA | NA | Promptb | DZP, PB | Alternating bil high ampl delta slow wave (+15 d)Normal (+18 d) |
aLess epileptiform elements and gradually more continuous background activity.
bDefined as seizure control within 3 min.
ampl, amplitude; ASMs, Antiseizure medications; asynch, ascynhronous; bil, bilateral; BS, Burst suppression; CBZ, carbamazepine; CLZ, clonazepam; d, day; DZP, diazepam; ED, Epileptiform Discharges; h, hour; L, left; LEV, levetiracetam; LDC, lidocaine; LTM, long-term monitoring; MDZ, midazolam; mo, month; MF, multifocal; NA, not applicable; o, occipital; PB, phenobarbital; PHT, phenytoin; PLP, pyridoxal 5 phosphate; PN, Pyridoxine; TPM, topiramate; VPA, valproate.