Table 5.
Outcomes of randomized controlled trials comparing dexamethasone vs. placebo.
| Reference (authors, year) | Extubation | Reintubation | BPD | Others respiratory outcome | Systemic hypertension | HG | Sepsis/infection | PDA | IVH | NEC | ROP | Long-term NDV | Long-term growth |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doyle (31) | NE | NE | NE | = | NE | NE | NE | NE | NE | NE | NE | At 2 years = | At 2 years = |
| Doyle (32) | + | = | = | + | = | = | = | = | = | = | = | NE | NE |
| Yeh (33) | NE | NE | + | + | NE | NE | = | NE | = | NE | = | At 8 years − | At 8 years − |
| Walther (34) | + | ND | = | = | = | − | = | NE | = | = | NE | NE | NE |
| Romagnoli (35) | NE | NE | + | NE | NE | NE | = | = | = | = | NE | 24 and 36 months of life = | 24 and 36 months of life = |
| Romagnoli (36) | + | ND | + | + | = | − | = | = | = | = | = | NE | NE |
| O'Shea (37) | NE | NE | + | NE | NE | NE | NE | NE | −a | NE | NE | At 1 year −b | At 1 years = |
| Kothadia (38) | ND | ND | + | + | = | = | = | NE | −a | = | = | NE | NE |
| Lin, 1999 (39) | = | ND | + | + | − | − | = | NE | = | NE | NE | NE | NE |
| Yeh (40) | + | ND | + | + | − | − | − | + | = | = | = | NE | NE |
| Suske (41) | + | ND | + | + | = | = | = | = | = | = | + | NE | NE |
| Brozanski (42) | ND | ND | + | + | NE | = | = | = | + | = | = | NE | NE |
| Durand (43) | + | ND | + | + | = | = | = | = | = | = | = | NE | NE |
| Kari (44) | ND | ND | NE | + | − | = | = | = | = | = | NE | NE | NE |
| Couser (45) | ND | + | ND | + | = | = | NE | NE | NE | NE | NE | NE | NE |
| Cummings (46) | + | = | NE | + | = | = | = | NE | NE | NE | = | 6 And 15 Months + | 6 And 15 Months = |
a
Abnormal cranial ultrasound.
b
Cerebral palsy.
+, Better outcome for intervention group (steroids administration); −, worse outcome for intervention group (steroids administration); =, no differences between intervention and control groups; NE, not evaluated; ND, not declared; BPD, bronchopulmonary dysplasia; HG, hyperglycemia; PDA, patent ductus arteriosus; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; ROP, retinopathy of prematurity; NDV, neurodevelopment; GA, gestational age; BW, birth weight.