Figure 2.

The composition of the gut microbiota influence the initiation and progression of intestinal diseases. The persistent existence of ROS within the intestinal environment is a key factor in the progression of disease, which plays an essential role in the initiation of chronic inflammation, immune responses and DNA damage. The gut-residing microbiota can generate metabolites endowed with antioxidant properties, thereby mitigating the extent of DNA damage resulting from oxidative stress. The dysbiotic gut microbiota significantly disrupt the intricate equilibrium between the generation of ROS and the process of detoxification, contributing to the development of intestinal diseases. SSB, single strand break; DSB double strand breaks. The figure was created with BioRender.com.