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. 2023 Dec 18;52(4):1930–1952. doi: 10.1093/nar/gkad1155

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 10. — AGO2 is enriched in the nucleus in 3D-cultured tumor spheroids. (A) Microscopy images of 3D-cultured HCT116 tumor spheroids. (B) Western blot showing AGO2 localization in 3D-HCT116 (N = 3). (C–E) Relative mRNA expression of candidate miRISC targets in 3D cultured HCT116 relative to parental 2D-cultured HCT116 cell line used to seed 3D culture. Significance denoted with *’s: (C) IGF1R, P= 0.0016, (D) OLFML2A, P= 0.036, (E) NOTCH3, P= 0.025.