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Depletion of miRNAs in DROSHA–/– restricts AGO2 localization to the cytoplasm. (A) Western blot showing AGO2 localization in isolated cytoplasm and nuclear fractions in Drosha–/– grown to high confluency (N = 3). (B) Immunofluorescence microscopy showing AGO2 localization in WT HCT116, DROSHA–/– cells, and DROSHA–/– cells transfected with microRNA mimics and control oligos.
