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. 2023 Dec 18;52(4):1930–1952. doi: 10.1093/nar/gkad1155

Figure 3.

Figure 3.

Loss of TNRC6A expression promotes AGO2 localization to the nucleus. (A) Western blot showing AGO2 localization in isolated cytoplasm and nuclear fractions in TNRC6AB–/– grown to high confluency (N = 3). (B) Western blot showing TNRC6A in whole cell lysate in WT HCT116 cells grown to high confluency (N = 3). (C) Co-immunoprecipitation of AGO2 and TNRC6A in WT HCT116 whole cell lysate at normal confluency (60%, Day 3) and high confluency without the presence of RNase (350%, Day 7) (N = 3). Rabbit IgG co-immunoprecipitation used as negative control.