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. 2023 Dec 18;52(4):1930–1952. doi: 10.1093/nar/gkad1155

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — miRISC target genes have longer half-lives in the cytoplasm when AGO2 is shifted to the nucleus. (A) Scheme for measuring RNA stability at low confluency (50%) and at high confluency (400%) in RNA isolated from cytoplasm and nuclear fractions at each time point (0–48 hrs). (B-E) mRNA stability assays for upregulated miRISC targets in RNA isolated from cytoplasm (B, D, F) and in RNA isolated from nuclei (C, E, G).