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. 2023 Nov 30;52(4):1544–1557. doi: 10.1093/nar/gkad1142

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Scheme representation on the diversity of miRNA interactomes. (A) Different miRNAs compete for cellular resources, including the available RISCs. There are specific preferences of the miRNAs for their interaction with different Ago paralogs as central part of the RISC. (B) Target mRNAs and competing endogenous RNA species, like circular RNAs (circRNAs), contest for miRNA binding. (C) Different mRNAs compete for RISC bound miRNAs. (D) RNA-binding proteins (RBPs) modulate accessibility of a mRNA target site for miRNAs. [Different miRNAs are depicted in red, pink and orange, respectively. Different mRNAs (targets) are shown in shades of blue and ceRNAs in violet. A different molecular abundance is indicated by a different number of miRNAs or mRNAs, respectively. RISCs are shown by turquoise and RNA binding proteins by greyish bodies. Functional interactions are indicated by arrows and sequence interactions by opposite comb-shaped lines.]