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Potential advantages of regulating miRNA expression via TDMD. (A) TDMD can deplete select miRNAs produced from a miRNA cluster. (B) TDMD can globally suppress expression of miRNAs expressed by paralogous genes at distant loci (chromosome map created with BioRender.com). (C) Coupled with transcription (signified by gray on/off arrows), TDMD can sharpen the dynamic expression of the miRNA, thus enabling the miRNA to reach a new steady state level more quickly.
