Table 5.

Recommended Best Practices to Reduce the Risk of Infusion-Site Adverse Events.

Practice aseptic technique when manipulating the infusion delivery system. •Prior to preparing the infusion set for use, wash hands with soap and water •Use a clean workspace when laying out the infusion set components •Clean the vial top with an alcohol wipe prior to puncturing with vial adapter •Clean the infusion site with soap and water prior to use. Then, before placing the cannula, wipe the skin with an alcohol wipe in an outward spiral formation (vs. back and forth) to avoid contaminating the insertion site •Avoid touching the tip of any disposable component (eg, syringe tip) •Allow the area to air dry (approximately 1 min) before placing the cannula

Avoid repenetration. Use a new cannula and select a new site instead.

Change the cannula and the infusion site immediately if unusual discomfort or irritation at the infusion site occurs. In the clinical trials, the infusion set and the infusion site could be left unchanged for up to 3 days (when the drug was infused continuously), but depending on the individual patient circumstances, the cannula and infusion site may require change more frequently than every 3 days. Indications to consider changing the cannula and infusion site more frequently than every 3 days include discomfort, irritation, skin reactions, or signs/symptoms of infusion-site AEs.

When finished with an infusion site, ensure that all drug product has been fully absorbed, and consider massaging the used infusion site to encourage absorption of any remaining drug product from the site. Patients should remember to use proper aseptic techniques while massaging previous infusion site areas.

If concerned about frequent cannula dislodgment issues, consider using commercially available medical tapes/ancillary adhesive materials. Medical tape/adhesives should be placed at least 5 cm from the cannula.

If concerned about infusion-site skin events (particularly cellulitis or abscess), initiate appropriate therapy or refer to an HCP knowledgeable about identification and management of infusion-site skin events in a timely manner.

AEs, adverse events; HCP, healthcare provider