Figure 2.

Prospective serum biomarkers with diagnostic potential in RA. (A) ROC curve analysis of proteins significantly altered in both early and established disease in the whole cohort of RA patients with the best capacity to identify RA (n=50) vs HDs (n=25) (Proteome model). (B) ROC curve analysis of commonly used diagnostic markers for RA, such as ACPAs, RF, and CRP (n=50) vs HDs (n=25) (Standard model). (C) Comparison of the ability to differentiate between RA patients and HDs using proteomic and standard models. RA, rheumatoid arthritis; HDs, healthy donors; ACPAs, antibodies to citrullinated protein antigens; RF, rheumatoid factor; CRP, C-reactive protein; ROC, receiver operating characteristic; AUC, area under the curve. Annotated names of abbreviated proteins ( Supplementary Table 1 ).