Table 1.
Descriptive clinical data of Rheumatoid Arthritis patients and healthy donors.
| HDs | Early RA | Established RA | |
|---|---|---|---|
| Size population | 25 | 25 | 25 |
| Female/male (%) | 78/22 | 75/25 | 70/30 |
| Age (years) | 58.55 ± 13.12 | 61.24 ± 12.65 | 63.75 ± 10.19 |
| Disease duration (years) | – | 0 | 37.48 ± 11.79b |
| Disease activity | |||
| DAS-28 (CRP) | – | 5.04 ± 1.20 | 4.82 ± 0.71 |
| CRP (mg/L) | 1.71 ± 1.94 | 1.48 ± 1.90 | 8.12 ± 7.39a,b |
| Autoimmunity profile | |||
| RF + (n) | – | 16 | 12 |
| ACPAs + (n) | – | 18 | 21 |
| CVD risk factors | |||
| Arterial Hypertension (%) | 12 | 20 | 36a |
| Obesity (%) | 12 | 16 | 36a |
| Smoking habit (%) | 12 | 24a | 24a |
| Type 2 Diabetes Mellitus (%) | 0 | 8 | 12a |
| Metabolic profile | |||
| Glucose (mg/dL) | 85.06 ± 9.66 | 89.62 ± 11.89 | 94.30 ± 22.98 |
| Total-cholesterol (mg/dL) | 198.50 ± 24.19 | 190.25 ± 32.91 | 202.90 ± 9.66 |
| HDL-cholesterol (mg/dL) | 58.65 ± 19.06 | 55.78 ± 21.83 | 65.33 ± 12.27 |
| LDL-cholesterol (mg/dL) | 119.20 ± 23.44 | 115.38 ± 32.08 | 112.86 ± 32.22 |
| Tryglicerides (mg/dL) | 99.94 ± 50.54 | 140.41 ± 94.15 | 103.73 ± 41.08 |
Data are represented by mean ± SD. HDs, healthy donors; RA, rheumatoid arthritis; DAS, disease activity score; CRP, c-reactive protein; RF, rheumatoid factor; ACPAs, antibodies to citrullinated protein antigens. aSignificant differences respect to HDs, p value < 0.05; bSignificant differences respect to early RA, p value < 0.05.