Table 1.
Enriched KEGG pathways by ORA and GSEA.
| Category | Sub-category | KEGG pathway | ORAa | GSEAb |
|---|---|---|---|---|
| Metabolism | Global and overview maps | Biosynthesis of cofactors | Down | Down (1C++) |
| Biosynthesis of amino acids | Down | Down | ||
| Energy metabolism | Oxidative phosphorylation | – | Up | |
| Lipid metabolism | Steroid biosynthesis | – | Down | |
| Linoleic acid metabolism | Up | Up (1C+) | ||
| Amino acid metabolism | Cysteine and methionine metabolism | Down | Down (1C++) | |
| Arginine biosynthesis | Down | – | ||
| Xenobiotics biodegradation and metabolism | Drug metabolism – cytochrome P450 | Down | – | |
| Metabolism of xenobiotics by cytochrome P450 | Up | – | ||
| Genetic Information Processing | Translation | Ribosome | – | Up |
| Aminoacyl-tRNA biosynthesis | – | Down (1C++) | ||
| Folding, sorting and degradation | Protein processing in endoplasmic reticulum | Up | Up (1C+) | |
| Protein export | Up | Up (1C+) | ||
| Cellular Processes | Cell growth and death | Cell cycle | – | Down |
aDown: enriched in C1 cluster, Up: enriched in C2 cluster, and “–”: not enriched by ORA. bDown and Up: enriched by both 1C+ and 1C++ groups with negative and positive NESs, respectively, but enriched only by one group when a group name (1C+ or 1C++) is followed. “–”: not enriched by GSEA.