Table 3.
List of top three DMCs identified by three different comparisons.
| Regiona | Gene symbolb | Gene name | 1C+ vs Ctrlc | 1C++ vs Ctrlc | 1C++ vs 1C+c | Function |
|---|---|---|---|---|---|---|
| P | rn182 | RING finger protein 182 | 6 (hyper) | 4 (hyper) | Ubiquitination | |
| - | uncharacterized LOC106572013 | 4 (hyper) | 4 (hypo) | - | ||
| styxl1 | serine/threonine/tyrosine-interacting protein A-like | 3 (hyper) | Translation, Signalling | |||
| loxl3 | lysyl oxidase homolog 3-like | 3 (hyper) | ||||
| yars | tyrosyl-tRNA synthetase | 4 (hypo) | Translation | |||
| top2b | DNA topoisomerase 2-beta-like | 2 (hyper) | Immune | |||
| nca11 | Neural cell adhesion molecule 1-A | 3 (hypo) | Cell adhesion | |||
| Flank (5K) | vngl | vang-like protein 1 | 5 (hyper) | Signalling | ||
| - | uncharacterized LOC106577634 | 6 (hyper) | 4 (hyper) | - | ||
| smu1-like | WD40 repeat-containing protein SMU1 | 1 (hyper) | 3 (hyper) | 2 (hyper) | Transcription | |
| hgf | hepatocyte growth factor-like | 1 (hyper) | 4 (hyper) | Signalling | ||
| csrnp3 | cysteine/serine-rich nuclear protein 3-like | 5 (hypo) | 2 (hyper) | Transcription | ||
| brf1 | transcription factor IIIB 90 kDa subunit-like | 2 (hypo) | 4 (hypo) | Transcription | ||
| btg4 | B-cell translocation gene 4 | 2 (hypo) | 8 (hyper) | Cell cycle | ||
| tbx15 | T-box 15 | 3 (both) | Adipose tissue regulation | |||
| GB (exon) | rnf186 | RING finger protein 186-like | 6 (hyper) | 4 (hyper) | Ubiquitination | |
| gcnt3 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3-like | 3 (hyper) | 4 (hyper) | Cell adhesion | ||
| st8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 5 (hypo) | 6 (hyper) | Cell adhesion | ||
| xirp2 | xin actin-binding repeat-containing protein 2-like | 5 (hypo) | Cell adhesion | |||
| cd276 | CD276 antigen-like | 5 (hypo) | 4 (hypo) | Immune | ||
| c3 | complement C3-like | 4 (hypo) | 4 (hypo) | Immune | ||
| lbh | protein LBH-like | 4 (hyper) | 2 (hypo) | 4 (hypo) | Signalling |
aP: promoter regions, Flank (5K): Flaking regions between 1K and 5K upstream from TSS, GB (exon): exons. bGene symbols from UniProt. cNumber of DMCs identified by three pair-wise comparisons. hypo, hyper, both: all DMCs are hypo- or hyper-methylated or both hypo and hyper-methylated, respectively.