Table 5.
Percentage of adults with chronic obstructive pulmonary disease who switched, stepped-down or stepped-up respiratory pharmacological treatment after the first-line treatment (broad definition)
| Label | CCAE (USA) | Medicaid (USA) | Medicare (USA) | EHIF (Estonia) | CPRD (UK) | SIDIAP (Spain) | IPCI (The Netherlands) | AUSOM (South Korea) |
| Step-up | 10.2 | 13.4 | 12.0 | 23.5 | 32.9 | 28.0 | 24.6 | 13.7 |
| Step-down | 6.6 | 7.8 | 7.5 | 13.7 | 13.3 | 14.6 | 12.1 | 16.6 |
| Switching | 8.6 | 11.3 | 9.4 | 9.2 | 25.4 | 17.0 | 10.8 | 9.6 |
| Start of acute exacerbation | 17.4 | 15.6 | 15.0 | 10.3 | 10.8 | 13.0 | 14.9 | 9.7 |
| End of acute exacerbation | 18.2 | 15.4 | 15.6 | 4.2 | 6.0 | 8.1 | 12.1 | 7.5 |
| No follow-up treatment* | 39.0 | 36.5 | 40.4 | 39.0 | 11.6 | 19.3 | 25.6 | 43.0 |
| Other | 0.04 | 0.01 | 0.01 |
*Patients who did not receive medication of a different respiratory drug class after the first treatment, that is, patients who remained on the same treatment or who discontinued treatment.