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. 2024 Feb 27;28:63. doi: 10.1186/s13054-024-04843-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The heatmap shows the difference in metabolomic profile using the most differentiating metabolites (VIP > 1.0) over five study groups. C19/A = SARS-CoV-2-induced ARDS patients admitted to ICU, C19/P = SARS-CoV-2-infected patients not sick enough to be admitted to ICU, H1N1/A = H1N1-induced ARDS patients admitted to ICU, PNA/A = bacterial pneumonia-induced ARDS patients admitted to ICU, CTL = non-ARDS ventilated control patients admitted to ICU. Relative metabolite concentrations are shown as indicated by a scale between −4 and + 4