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. 2024 Feb 27;22:210. doi: 10.1186/s12967-024-04848-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Endothelial cell expression heterogeneity. A UMAP plot of endothelial cells, color-coded by cell subtypes. B Enrichment heatmap of different endothelial cell subtypes across various ISUP grades of tumor tissue. C Impact of CRHBP⁺ CAP endothelial cell enrichment on patient prognosis. D Differential genes among cell subtypes derived from tumor and normal sources: Left-Arterial endothelial cells; Middle-Capillary endothelial cells; Right-Venous endothelial cells. E UMAP plot of endothelial cells, color-coded by expression of ENPP2 gene. F Patient prognosis stratified by ENPP2 expression levels. ISUP: International Society of Urological Pathology.UMAP: Uniform Manifold Approximation and Projection