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. 2024 Feb 28;221(4):e20221080. doi: 10.1084/jem.20221080

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© 2024 Zhang et al.

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Figure 4. — Autoimmune triggers induced exacerbated autoimmunity in Sh2b3^E372K mice. (A and B) Serum ANAs (A; +/+: n = 14, E372K/+: n = 4, E372K/E372K: n = 13) and anti-DNA IgG (B; +/+: n = 15, E372K/+: n = 8, E372K/E372K: n = 15) determined by ELISA. One-way ANOVA was used for statistical analyses. Results are pooled from two to four separate mouse cohorts and representative to two independent experiments. (C) Experimental plan of pristane-induced lupus-like autoimmune model in Sh2b3^E372K mice. 14-wk-old female Sh2b3^E372K mice were bled 1 day before the IP injection of 0.25-ml pristane or PBS (control) and later 2-, 10-, and 20-wk after injection and sacrificed 24-wk after injection for spleen and kidney analysis. (D–I) Levels of serum anti-DNA IgG in pristane-treated mice at 0 (D), 10 (E), and 20 (F) weeks after treatment, and PBS-treated mice at 0 (G), 10 (H), and 20 (I) weeks after treatment. Means are shown as bars in all dot plots. Data were pooled from two independent experiments, +/+: n = 8, E372K: n = 5, E372K/E372K: n = 11. Statistical analyses performed using lmer ANOVA; *: P < 0.05.