Table 2.

Advantages and disadvantages of different vaccine types.

Vaccine type	Advantages	Disadvantages	Principle of generation
Inactivated vaccines	High safety for immunosuppressed people. Better stability for storage.	Low immunogenicity Need adjuvants or multiple doses to enhance immunity.	Composed of viral particles along with other pathogens that were cultured.
Live-attenuated vaccines	Persistent immune response without adjuvants or multiple doses.	Not recommended for immunosuppressed people or gravidas because of potential hazards.	Reduce the virulence of a pathogen while maintaining its activity.
DNA vaccines	Better stability for storage. Better perform vaccine design by adding or deleting.	Low immunogenicity. Low therapeutic efficacy due to the degradation of DNA.	An antigen from a pathogen is cloned and inserted into the DNA plasmid.
mRNA vaccines	Provide a better safety profile because of less insertional mutations.	Low-temperature storage owing to instability. Need to boost immunization.	Synthesized with the virtually desired sequence.
Viral vectored vaccines	Induce stronger immune responses.	Not recommended for immunocompromised persons or gravidas.	Insert genes encoding the proteins of pathogenic microorganisms into the vector.