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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Physiol. 2023 Apr 25;601(13):2733–2749. doi: 10.1113/JP284244

Figure 4. Modifications made to published hPSC-CM model.

Figure 4.

A, schematic representation showing modifications made to ionic model. IK1 was blocked and If was doubled. B, RTqPCR analysis of wild-type hPSC-CMs at day 14 after differentiation. Data shown as means (SD) of 3 independent biological replicates. HK, housekeeping gene. Statistical differences are reported by one-way ANOVA with Šidák’s correction. Bolded P-values denote statistical significance. C, action potential traces of published model (black) compared to modified model (red). The spontaneous beating rate of modified model showed an increased beating rate of 1.9 Hz compared to 1.1 Hz in the published model.