. 2024 Feb 21;626(8001):1094–1101. doi: 10.1038/s41586-024-07029-4

Table 2.

Recurrent mutations and deletions identified during persistent SARS-CoV-2 infections

Gene	Mutation	n	Lineage	Description
S	T547K	2	BA.2	Lineage-defining for BA.1
S	L452R	2	BA.2	Lineage-defining for Delta and BA.4/5^a
S	T376A	2	BA.1	Lineage-defining for BA.2/4/5
S	T95I	1	BA.2	Lineage-defining for BA.1^a
S	G446V/D	2	Delta and BA.2	Target for monoclonal antibodies
S	D215G	1	BA.2	Lineage-defining for Beta^a
S	ΔA243/L244	3	Alpha and BA.2	Lineage-defining for Beta^a
S	ΔY144	1	BA.2	Lineage-defining for Alpha and BA.1
ORF1ab	L5905F	2	BA.1 and BA.2	Commonly found in Mu and Delta
ORF1ab	T4175I	2	BA.1	Commonly found in BA.2
ORF1ab	T1638I	2	BA.2	^a
ORF1ab	D4532D	1	BA.2	^a
ORF1ab	Δ81–86	12	Delta, BA.1 and BA.2	^a
ORF8	I121L	1	BA.1	^a

See Source Data Fig. 2 for more information about all mutations. Δ, deletion. ^aRecurrent in immunocompromised patients.