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. 2024 Feb 7;626(8001):1133–1140. doi: 10.1038/s41586-024-07027-6

Fig. 4. RNase R-mediated 30S subunit degradation involves a major head rearrangement.

Fig. 4

a,b, Comparison of the cryo-EM maps of RNase R (orange) in the 30S degradation state I (a) and in degradation state II (b). In both states the body of the ribosome has in the same orientation for reference. c, Comparison of the binding position of RNase R in state I (top) and in state II (bottom), with h24 (pink) and uS11 (green) for reference. d,e, Comparison of the head in state I (d) and state II (e), with the head rRNA (pale yellow) and the beak (red) coloured. f, Imaginary axes around which the 30S head and RNase R rotate to interconvert between states I and II. g,h, Relative binding positions of RNase R in state I (g) and state II (h), illustrating the shift in the RNB (orange) and S1 (yellow) domains. i, Proximity of RNase R (orange) to the 3′ end of the 16 rRNA (red) in state II, with neighbouring ribosomal proteins (R-proteins) (blue) and head rRNA (yellow) coloured.