Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 28;15:1819. doi: 10.1038/s41467-024-46234-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Voltage clamp recordings of SACs. Currents evoked by short (left) and long (right) depolarizing steps were recorded before and after the application of N and P/Q type calcium channel antagonists ω-conotoxin (CTX) and ω-Agatoxin IVA (AgTX). Arrowheads indicate peaks of fast calcium currents. Regenerative calcium spikes are present during long depolarization (upper right traces) and fully blocked by Ca channel antagonists. Modified from Koren. et al., 2015, Fig. S4. b Example traces of paired SAC-DSGC voltage clamp recording from a null side SAC-DSGC pair. Dashed vertical lines indicate the relative time between the presynaptic SAC calcium currents and the postsynaptic DSGC EPSC (left) and IPSC (right). c Currents of a SAC in response to deploarizing voltage steps before and after application of LY341395. d Left: Currents of a SAC in response to different levels of 200 ms voltage steps before and after LY341495. Right: Vm threshold of calcium currents before and after LY341495. Lines connect the same cells before and after LY application. Two-sided paired student t test, p = 0.0002, n = 10 cells. Source data are provided as a Source Data file.