Fig. 3.

AiV-A1 A846/88 infects absorptive and proliferative enterocytes and replicates in patient-derived ileum. (A) Immunofluorescence micrographs of HIE after CVB3 and AiV-A1 A846/88 infection (each with 10⁷ PFU) co-stained for dsRNA (red) and for the absorptive or proliferative enterocyte marker ApoA1 and Ki-67 (green), respectively. Dashed lines indicate cell outlines. (B) Patient-derived distal ileal tissue immunostained for dsRNA (red) after AiV-A1 A846/88 infection (10⁷ PFU). Dashed lines indicate luminal interface. White boxes represent zoomed areas shown at the right. Scale bars, 10 μm.