Table 2.
Genotype and allele frequencies of two H19 SNPs in study groups by gender (n, %)
| Genotypes/Alleles of rs2839698 | Genotypes/Alleles of rs217727 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C/C | C/T | T/T | χ2 | P | C | T | χ2 | P | C/C | C/T | T/T | χ2 | P | C | T | χ2 | P | |
| Normal controls | ||||||||||||||||||
| Males (n = 99) | 50 (50.5) | 35 (35.4) | 14 (14.1) | 135 (68.2) | 63 (31.8) | 37 (37.4) | 52 (52.5) | 10 (10.1) | 126 (63.6) | 72 (36.4) | ||||||||
| Females (n = 293) | 153 (52.5) | 118 (40.3) | 22 (7.5) | 424 (72.4) | 162 (27.6) | 144 (49.1) | 124 (42.3) | 25 (8.5) | 412 (70.3) | 174 (29.7) | ||||||||
| Total (n = 392) | 203 (51.8) | 153 (39) | 36 (9.2) | 559 (71.3) | 225 (28.7) | 181 (46.2) | 176 (44.9) | 35 (8.9) | 538 (68.9) | 246 (31.4) | ||||||||
| Obese group | ||||||||||||||||||
| Males (n = 54) | 4 (7.4) | 34 (63) | 16 (29.6) | 28.5 | <0.0001 | 42 (38.9) | 66 (61.1) | 24.6 | <0.0001 | 34 (63) | 18 (33.3) | 2 (3.7) | 9.56 | 0.008 | 86 (79.6) | 22 (20.4) | 10.6 | 0.001 |
| Females (n = 360) | 35 (9.7) | 244 (67.8) | 81 (22.5) | 146 | <0.0001 | 314 (43.6) | 406 (56.4) | 108 | <0.0001 | 212 (58.9) | 139 (38.6) | 9 (2.5) | 14.6 | 0.001 | 563 (78.2) | 157 (21.8) | 8.4 | 0.004 |
| Total (n = 414) | 39 (9.4) | 278 (67.1) | 97 (23.4) | 175 | <0.0001 | 356 (43) | 472 (57) | 132 | <0.0001 | 246 (59.4) | 157 (37.9) | 11 (2.7) | 22.9 | <0.0001 | 649 (78.4) | 179 (21.6) | 19.7 | <0.0001 |
According to the SNP database, the wildtype alleles for both rs2839698 and rs217727 are C on minus strand. The T alleles were the minor allele for both SNPs and considered as effect alleles
C/C, homozygous reference; C/T, heterozygous and T/T, homozygous mutant for rs2839698 SNP (based on SNP database)
C/C, homozygous reference; C/T, heterozygous and T/T, homozygous mutant for rs217727 SNPs (based on SNP database)
Genotype frequencies are shown in parentheses. χ2 test and P value are presented for obese groups vs. normal BMI control subjects