Table 4.
Bone- and joint characteristics in children and adults with XLH in the Netherlands
| Total N = 80 | Children N = 29 | Adults N = 51 | |
|---|---|---|---|
| Bone deformities | |||
| Deformity of the spine, n(%) | 6 (7.5%) | 1 (3.4%) | 5 (9.8%) |
| Deformity of the hips | 10 (12.5%) | 2 (6.9%) | 8 (15.7%) |
| Bowing of the femora, n(%) | 16 (20.0%) | 5 (17.2%) | 11 (21.6%) |
| Deformity of the knee, n(%) | 60 (75.0%) | 25 (86.2%) | 35 (68.6%) |
| Genu varum | 43 (53.8%) | 13 (44.8%) | 30 (58.8%) |
| Genu valgum | 25 (31.3%) | 15 (51.7%) | 10 (19.6%) |
| Bowing of the lower legs, n(%) | 9 (11.3%) | 5 (17.2%) | 4 (7.8%) |
| Osteoarthritis | |||
| Osteoarthritis of any joint, n(%) | 26 (32.5%) | – | 26 (51.0%) |
| Osteoarthritis of the hip, n(%) | 15 (18.8%) | – | 15 (29.4%) |
| Osteoarthritis of the knee, n(%) | 13 (16.3%) | – | 13 (25.5%) |
| (pseudo)Fractures | |||
| History of a (pseudo)fracture, n(%) | 18 (22.5%) | 3 (10.3%) | 15 (29.4%) |
| Age of first (pseudo)fracture | 24.0 (5.3 to 54.0) | 6.5 (5.3 to 7.0) | 34.7 (11.8 to 54.0) |
| Number of (pseudo)fractures | 1.5 (1.0 to 14.0) | 1.0 (1.0 to 1.0) | 2.0 (1.0 to 14.0) |
| (pseudo)Fracture location, n(%) | |||
| Vertebrae | 1 (5.6%) | – | 1 (6.7%) |
| Upper arm | 1 (5.6%) | 1 (33.3%) | – |
| Hand/wrist | 2 (11.1%) | – | 2 (13.3%) |
| Rib | 2 (11.1%) | – | 2 (13.3%) |
| Upper leg | 4 (22.2%) | 1 (33.3%) | 3 (20.0%) |
| Lower leg | 3 (16.7%) | – | 3 (20.0%) |
| Foot | 8 (44.4%) | 1 (33.3%) | 7 (46.7%) |
Continuous values are displayed as median (range), categorical variables are displayed in absolute counts (%)