Figure 2.

The JAKs/STAT signaling pathway is activated through cytokine (A) Inflammatory cytokines bind to the receptor, dimerizing it, activating JAKs, and phosphorylating the intracellular portion of the receptor. (B) STAT proteins bind at sites containing phosphorylated tyrosine. (C) STAT dimerizes and translocates into the nucleus to regulate gene expression. IL, interleukin; INF, interferon; JAKs and STAT, Janus kinases and Signal Transducers and Activators of Transcription (Created with BioRender.com).