Table 8.
Network enrichment pathways identified by the KEGG global metabolic network analysis that are significantly altered by the high-fat diet or time-restricted feeding of the high-fat diet.
| Metabolic pathways | Match status a | p b |
|---|---|---|
| Control vs high-fat diet | ||
| Aminoacyl-tRNA biosynthesis | 6/22 | < 0.01 |
| Glutathione metabolism | 4/19 | < 0.01 |
| High-fat diet vs time-restricted feeding | ||
| Aminoacyl-tRNA biosynthesis | 7/22 | < 0.01 |
| Glutathione metabolism | 4/19 | < 0.01 |
| Phenylalanine, tyrosine, and tryptophan biosynthesis | 2/4 | 0.04 |
| Control vs time-restricted feeding | ||
| Aminoacyl-tRNA biosynthesis | 10/22 | < 0.01 |
| Alanine, aspartate, and glutamate metabolism | 6/28 | < 0.01 |
a
Number of identified metabolites that match to pathway metabolites.
b
FDR-adjusted p values.